CCL14

Hemokin (C-C motiv) ligand 14
Identifikatori
SimbolCCL14
Alt. simboliSCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF
Entrez6358
HUGO10612
OMIM601392
RefSeqNM_032962
UniProtQ16627
Ostali podaci
LokusHromozom 17 q11.2

CCL14, hemokin (C-C motiv) ligand 14, je mali citokin iz CC hemokin familije. On je takođe poznat kao HCC-1. On se proizvodi kao proteinski prekurzor koji podleže modifikacijama da bi formirao krajnji aktivni protein koji sadrži 74 aminokiseline. On je 46% identičan po aminokiselinskoj kompoziciji sa CCL3 i CCL4. Ovaj hemokin je izražen u nizu tkiva uključujući slezinu, koštanu srž, jetru, mišiće, i creva.[1] CCL14 activira monocite, ali ne indukuje njihovu hemotaksu. Ljudski CCL14 se nalazi na hromozomu 17 u klasteru sa drugim hemokinima iz CC familuje.[2][3]

Reference

  1. ^ Schulz-Knappe; et al. (1996). „HCC-1, a novel chemokine from human plasma.”. J. Exp. Med.. 183: 295—299. 
  2. ^ Naruse; et al. (1996). „A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2”. Genomics. 34: 236—240. 
  3. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

Spoljašnje veze

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