CCL25

Hemokin (C-C motiv) ligand 25
Identifikatori
SimbolCCL25
Alt. simboliSCYA25, TECK, Ckb15
Entrez6370
HUGO10624
OMIM602565
RefSeqNM_005624
UniProtO15444
Ostali podaci
LokusHromozom 19 p13.2

CCL25, hemokin (C-C motiv) ligand 25, je mali citokin iz CC hemokin familije koji je takođe poznat kao TECK (timusom izražen hemokin). Za CCL25 se veruje da učestvuje u razvoju T-ćelija.[1] On je hemotaksan za timocite, makrofage, i dendritske ćelije. CCL25 destvuje vezivanjem za hemokinski receptor CCR9.[2][3] Ljudski CCL25 nastaje kao protein prekurzor koji sadrži 151 aminokiselina. CCL25 gen (scya25) je lociran na ljudskom hromozomu 19.[4][5]

Reference

  1. ^ Vacari; et al. (1997). „TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development”. Immunity. 7: 291—301. 
  2. ^ Zaballos; et al. (1999). „Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK”. J. Immunol.. 162: 5671—5675. 
  3. ^ Gosling; et al. (2000). „Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK”. J Immunol. 164: 2851—6. 
  4. ^ Nomiyama; et al. (1998). „The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2”. Genomics. 51: 311—312. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

Spoljašnje veze

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