CCL16

chemokine (C-C motif) ligand 16
Identifikatori
SimbolCCL16
Alt. simboliSCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1
Entrez6360
HUGO10614
OMIM601394
RefSeqNM_004590
UniProtO15467
Ostali podaci
LokusHromozom 17 q11.2

CCL16, hemokin (C-C motif) ligand 16, je mali citokin iz CC hemokin familije koji je poznat pod nekoliko pseudonima, uključujući LEC (engl. Liver-expressed chemokine - hemokin izražen u jetri), i monotaktin-1 (MTN-1). Ovaj hemokin je izražen u jetri, timusu, i slezini. On je hemoatraktant za monocite i limfocite.[1] CCL16 ćelijska ekspresija se može jako indukovati u monocitima sa IL-10, IFN-γ i bakterijskim lipopolisaharidima. Njegov gen je lociran na hromozomu 17 kod ljudi, u klasteru sa drugim CC hemokinima.[2] CCL16 dejstvuje na ćelije putem interakcija sa hemokinskim receptorima na ćelijskoj površini kao što su CCR1, CCR2, CCR5 i CCR8.[3][4][5]

Reference

  1. ^ Youn; et al. (1998). „Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity.”. Biochem. Biophys. Res. Commun.. 247: 217—222. 
  2. ^ Nomiyama; et al. (1999). „Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.”. J. Interferon Cytokine Res.. 19: 227—234. 
  3. ^ Nomiyama; et al. (2001). „Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes.”. Int Immunol. 13 (8): 1021—9. 
  4. ^ Howard; et al. (2000). „LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.”. Blood. 96 (3): 840—5. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

Spoljašnje veze

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