CCL13

Hemokin (C-C motiv) ligand 13
Identifikatori
SimbolCCL13
Alt. simboliSCYA13, MCP-4, NCC-1, SCYL1, CKb10
Entrez6357
HUGO10611
OMIM601391
RefSeqNM_005408
UniProtQ99616
Ostali podaci
LokusHromozom 17 q11.2

CCL13, hemokin (C-C motiv) ligand 13, je mali citokin iz CC hemokin familije. Njegov gen se nalazi na ljudskom hromozomu 17 unutar velikog klastera CC hemokina.[1][2] CCL13 indukuje hemotaksu monocita, eozinofila, T limfocita, i bazofila putem vezivanja za G-protein spregnute hemokin receptore kao što su CCR2, CCR3 i CCR5.[3] Aktivnost ovog hemokina je bila implicirana u alergijske reakcije kao što je astma.[4] CCL13 može biti indukovan inflamatornim citokinima interleukin 1 i TNF-α.[5]

Reference

  1. ^ Garcia-Zepeda EA,; et al. (1996). „Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3”. J Immunol. 157: 5613—5626. 
  2. ^ Naruse; et al. (1996). „A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2”. Genomics. 34 (2): 236—40. 
  3. ^ Blanpain; et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist”. Blood. 94: 1899—905. 
  4. ^ Lamkhioued; et al. (2000). „Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines”. Am J Respir Crit Care Med. 162: 723—32. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

Spoljašnje veze

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