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Hemokin (C-C motiv) ligand 4
Hemokin (C-C motiv) ligand 4
	PDB prikaz baziran na 1hum.
Dostupne strukture
	1hum, 1hun, 1je4, 2ffk, 2fin
Identifikatori
Simboli	CCL4; SCYA4; ACT2; AT744.1; G-26; LAG1; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP1B
Vanjski ID	OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptor signalne protein tyrozin kinaze; • hemokinska aktivnost;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor;
Biološki proces	• ćelijska pokretljivost; • hemotaksa; • inflamatorni respons; • imunski respons; • ćelijska adhezija; • uspostavljanje i/ili održavanje ćelijske polarnosti; • prenos signala; • interćelijska signalizacija; • respons na viruse; • replikacija viralnog genoma;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6351
Ensembl	ENSG00000129277
UniProt	P13236
RefSeq (mRNA)	NM_002984
RefSeq (protein)	NP_002975
Lokacija (UCSC)	Chr 17:; 31.46 - 31.46 Mb
PubMed pretraga	[1]

CCL4, hemokin (C-C motiv) ligand 4, je protein koji je kod ljudi kodiran CCL4 genom.^[1]^[2]

Funkcija

CCL4 je CC chemokin koji je specifičan za CCR5 receptore. On je hemoatraktant za NK ćelije, monocite i niz drugih imunskih ćelija.^[3]

CCL4 je značajan HIV-supresujući faktor koji proizvode CD8+ T ćelije.^[4] Perforin memorijske CD8+ T ćelije normalno sintetišu MIP-1-beta.^[5]

Interakcije

Za CCL4 je bilo pokazano da interaguje sa CCL3.^[6]

Vidi još

Macrofag inflamatorni protein

Reference

^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (1990). „Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q”. Nucleic Acids Res.. 18 (11): 3261—70. PMC 330932 . PMID 1972563. doi:10.1093/nar/18.11.3261.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (2001). „B cells and professional APCs recruit regulatory T cells via CCL4”. Nat. Immunol.. 2 (12): 1126—32. PMID 11702067. doi:10.1038/ni735.
^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995). „Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells”. Science (journal). 270 (5243): 1811—5. PMID 8525373.
^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (2001). „Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta”. Proc. Natl. Acad. Sci. U.S.A.. 98 (16): 9283—8. PMC 55412 . PMID 11470920. doi:10.1073/pnas.161298998.
^ Guan, E; Wang J; Norcross M A (2001). „Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer”. J. Biol. Chem.. United States. 276 (15): 12404—9. ISSN 0021-9258. PMID 11278300. doi:10.1074/jbc.M006327200.

Literatura

Menten P, Wuyts A, Van Damme J (2002). „Macrophage inflammatory protein-1.”. Cytokine Growth Factor Rev.. 13 (6): 455—81. PMID 12401480. doi:10.1016/S1359-6101(02)00045-X.
Muthumani K; Desai BM; Hwang DS (2004). „HIV-1 Vpr and anti-inflammatory activity.”. DNA Cell Biol.. 23 (4): 239—47. PMID 15142381. doi:10.1089/104454904773819824.
Conti L; Fantuzzi L; Del Cornò M (2005). „Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.”. Immunobiology. 209 (1-2): 99—115. PMID 15481145. doi:10.1016/j.imbio.2004.02.008.
Joseph AM, Kumar M, Mitra D (2005). „Nef: "necessary and enforcing factor" in HIV infection.”. Curr. HIV Res.. 3 (1): 87—94. PMID 15638726. doi:10.2174/1570162052773013.
Zhao RY, Elder RT (2005). „Viral infections and cell cycle G2/M regulation.”. Cell Res.. 15 (3): 143—9. PMID 15780175. doi:10.1038/sj.cr.7290279.
Zhao RY, Bukrinsky M, Elder RT (2005). „HIV-1 viral protein R (Vpr) & host cellular responses.”. Indian J. Med. Res.. 121 (4): 270—86. PMID 15817944.
Li L; Li HS; Pauza CD (2006). „Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.”. Cell Res.. 15 (11-12): 923—34. PMID 16354571. doi:10.1038/sj.cr.7290370.
King JE, Eugenin EA, Buckner CM, Berman JW (2006). „HIV tat and neurotoxicity.”. Microbes Infect.. 8 (5): 1347—57. PMID 16697675. doi:10.1016/j.micinf.2005.11.014.
Napolitano M; Modi WS; Cevario SJ (1991). „The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.”. J. Biol. Chem.. 266 (26): 17531—6. PMID 1894635.
Irving SG; Zipfel PF; Balke J (1990). „Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q.”. Nucleic Acids Res.. 18 (11): 3261—70. PMC 330932 . PMID 1972563. doi:10.1093/nar/18.11.3261.
Baixeras E; Roman-Roman S; Jitsukawa S (1991). „Cloning and expression of a lymphocyte activation gene (LAG-1).”. Mol. Immunol.. 27 (11): 1091—102. PMID 2247088. doi:10.1016/0161-5890(90)90097-J.
Lipes MA; Napolitano M; Jeang KT (1989). „Identification, cloning, and characterization of an immune activation gene.”. Proc. Natl. Acad. Sci. U.S.A.. 85 (24): 9704—8. PMC 282843 . PMID 2462251. doi:10.1073/pnas.85.24.9704.
Brown KD, Zurawski SM, Mosmann TR, Zurawski G (1989). „A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.”. J. Immunol.. 142 (2): 679—87. PMID 2521353.
Zipfel PF; Balke J; Irving SG (1989). „Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.”. J. Immunol.. 142 (5): 1582—90. PMID 2521882.
Chang HC, Reinherz EL (1989). „Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.”. Eur. J. Immunol.. 19 (6): 1045—51. PMID 2568930. doi:10.1002/eji.1830190614.
Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). „A novel polypeptide secreted by activated human T lymphocytes.”. J. Immunol.. 143 (9): 2907—16. PMID 2809212.
Adams MD; Kerlavage AR; Fleischmann RD (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.”. Nature. 377 (6547 Suppl): 3—174. PMID 7566098.
Post TW; Bozic CR; Rothenberg ME (1995). „Molecular characterization of two murine eosinophil beta chemokine receptors.”. J. Immunol.. 155 (11): 5299—305. PMID 7594543.
Combadiere C, Ahuja SK, Murphy PM (1995). „Cloning and functional expression of a human eosinophil CC chemokine receptor.”. J. Biol. Chem.. 270 (28): 16491—4. PMID 7622448. doi:10.1074/jbc.270.28.16491.
Paolini JF; Willard D; Consler T (1994). „The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations.”. J. Immunol.. 153 (6): 2704—17. PMID 8077676.

Spoljašnje veze

CCL4 GeneCard

[pmid1972563-1] Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (1990). „Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q”. Nucleic Acids Res.. 18 (11): 3261—70. PMC 330932 . PMID 1972563. doi:10.1093/nar/18.11.3261.

[2] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid11702067-3] Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (2001). „B cells and professional APCs recruit regulatory T cells via CCL4”. Nat. Immunol.. 2 (12): 1126—32. PMID 11702067. doi:10.1038/ni735.

[pmid8525373-4] Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995). „Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells”. Science (journal). 270 (5243): 1811—5. PMID 8525373.

[pmid11470920-5] Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (2001). „Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta”. Proc. Natl. Acad. Sci. U.S.A.. 98 (16): 9283—8. PMC 55412 . PMID 11470920. doi:10.1073/pnas.161298998.

[pmid11278300-6] Guan, E; Wang J; Norcross M A (2001). „Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer”. J. Biol. Chem.. United States. 276 (15): 12404—9. ISSN 0021-9258. PMID 11278300. doi:10.1074/jbc.M006327200.

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CCL4