CCL27

Hemokin (C-C motiv) ligand 27
Identifikatori
SimbolCCL27
Alt. simboliSCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
Entrez10850
HUGO10626
OMIM604833
RefSeqNM_006664
UniProtQ9Y4X3
Ostali podaci
LokusHromozom 9 q13

CCL27, hemokin (C-C motiv) ligand 27, je mali citokin iz CC hemokin familije koji je takođe poznat pod imenima IL-11 R-alfa-lokus hemokin (ILC), skinkin, ESkin i kožni T-ćelijski atraktivni hemokin (CTACK). On je asociran sa navođenjem memorijskih T limfocita ka koži, i on učestvuje u T ćelijama posredovanoj inflamaciji kože.[1][2] CCL27 je izražen u brojnim tkivima, među kojima su gonade, timus, posteljica i koža. On ispoljava svoje hemotaksne efekte vezivanjem za hemokinski receptor CCR10.[3] CCL27 gen je lociran na ljudskom hromozomu 9.[4][5]

Reference

  1. ^ Morales; et al. (1999). „CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells”. Proc. Natl. Acad. Sci. U.S.A.. 96: 14470—14475. 
  2. ^ Homey; et al. (2002). „CCL27-CCR10 interactions regulate T cell-mediated skin inflammation”. Nature Med. 8: 157—165. 
  3. ^ Homey; et al. (2000). „The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)”. J. Immunol.. 164: 3465—3470. 
  4. ^ Ishikawa-Mochizuki; et al. (1999). „Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus”. FEBS Lett. 460: 544—548. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

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