CCL9

Hemokin (C-C motiv) ligand 9
Identifikatori
Simboli CCL9; CCF18; MRP-2; Scya9; Scya10; Ccl9
Vanjski ID MGI: 104533 HomoloGene: 86734
Ortolozi
Vrsta Čovek Miš
Entrez n/a 20308
Ensembl n/a ENSMUSG00000019122
UniProt n/a P51670
RefSeq (mRNA) n/a NM_011338
RefSeq (protein) n/a NP_035468
Lokacija (UCSC) n/a Chr 11:
83.39 - 83.39 Mb
PubMed pretraga n/a [1]

CCL9, hemokine (C-C motiv) ligand 9, je mali citokin iz CC hemokin familije. On se naziva makrofagni inflamatorni protein-1 gama (MIP-1γ), protein-2 koji je sličan macrofagnom inflamatornom proteinu (MRP-2) i CCF18. Bio je opisan kod glodara. CCL9 je ranije imao oznaku CCL10. Ta oznaka se više ne koristi. On se izlučuje iz folikl-asociranog epitelijuma (FAE). CCL9 privlači dendritske ćelije koje poseduju CD11b molekule na ćelijskoj površini i hemokin receptor CCR1.[1] CCL9 može da aktivira osteoklaste putem njegovog receptora CCR1 (koji je najobilniji hemokin receptor na osteoklastima) što ide u podršku važnosti CCL9 uloge u resoprciji kostiju.[2] CCL9 je konstitutivno izražen u makrofagama i mijeloidnim ćelijama.[3][4] Gen za CCL9 je lociran na hromozomu 11 kod miševa.[4][5]

Reference

  1. ^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). „CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells”. J Immunol. 171 (6): 2797—803. PMID 12960300. 
  2. ^ Lean J, Murphy C, Fuller K, Chambers T (2002). „CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts”. J Cell Biochem. 87 (4): 386—93. PMID 12397598. doi:10.1002/jcb.10319. 
  3. ^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). „A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors”. J Immunol. 155 (5): 2661—7. PMID 7650394. 
  4. ^ а б Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). „Molecular cloning and functional characterization of a novel member of the C-C chemokine family”. J Immunol. 155 (11): 5352—8. PMID 7594550. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

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