FZD7
| Uvojiti receptor 7 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | FZD7; FzE3 | ||||||||||
| Vanjski ID | OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8324 | 14369 | |||||||||
| Ensembl | ENSG00000155760 | ENSMUSG00000041075 | |||||||||
| UniProt | O75084 | Q810L8 | |||||||||
| RefSeq (mRNA) | NM_003507.1 | NM_008057.3 | |||||||||
| RefSeq (protein) | NP_003498.1 | NP_032083.3 | |||||||||
| Lokacija (UCSC) |
Chr 2: 202.9 - 202.9 Mb |
Chr 1: 59.54 - 59.54 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Uvojiti-7 je protein koji je kod ljudi kodiran FZD7 genom.[1][2][3]
Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskim karcinomima jednjaka.[3]
Interakcije
FZD7 formira interakcije sa DLG4.[4]
Reference
- ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A. 95 (17): 10164—9. PMC 21479
. PMID 9707618. doi:10.1073/pnas.95.17.10164.
- ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun. 252 (1): 117—22. PMID 9813155. doi:10.1006/bbrc.1998.9607.
- ^ а б „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.
- ^ Hering, Heike; Sheng Morgan (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett.. Netherlands. 521 (1–3): 185—9. ISSN 0014-5793. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.
Literatura
- Finch PW; He X; Kelley MJ (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A.. 94 (13): 6770—5. PMC 21233 . PMID 9192640. doi:10.1073/pnas.94.13.6770.
- Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett.. 521 (1–3): 185—9. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.
- Strausberg RL; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”. Oncogene. 23 (36): 6023—30. PMID 15195140. doi:10.1038/sj.onc.1207817.
- Omoto S; Hayashi T; Kitahara K (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet.. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
- Gerhard DS; Wagner L; Feingold EA (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Vincan E; Darcy PK; Smyth MJ (2005). „Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth”. Differentiation. 73 (4): 142—53. PMID 15901282. doi:10.1111/j.1432-0436.2005.00015.x.
- Rual JF; Venkatesan K; Hao T (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
- Lim J; Hao T; Shaw C (2006). „A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801—14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
- Vincan E; Darcy PK; Farrelly CA (2007). „Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids”. Oncogene. 26 (16): 2340—52. PMID 17016432. doi:10.1038/sj.onc.1210026.
- Struewing IT; Barnett CD; Zhang W (2007). „Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1”. Exp. Cell Res.. 313 (16): 3526—41. PMID 17716656. doi:10.1016/j.yexcr.2007.07.012.
Vidi još
Spoljašnje veze
- „Frizzled Receptors: FZD7”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г..
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