P2RY1
| Purinski receptor P2Y, G-protein spregnuti, 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | P2RY1; P2Y1 | ||||||||||
| Vanjski ID | OMIM: 601167 MGI: 105049 HomoloGene: 1926 IUPHAR: P2Y1 GeneCards: P2RY1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5028 | 18441 | |||||||||
| Ensembl | ENSG00000169860 | ENSMUSG00000027765 | |||||||||
| UniProt | P47900 | Q544J5 | |||||||||
| RefSeq (mRNA) | NM_002563 | NM_008772 | |||||||||
| RefSeq (protein) | NP_002554 | NP_032798 | |||||||||
| Lokacija (UCSC) |
Chr 3: 154.04 - 154.04 Mb |
Chr 3: 61.09 - 61.1 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
P2Y purinoceptor 1 je protein koji kod je kod ljudi kodiran P2RY1 genom.[1]
Produkt ovog gena, P2Y1 pripada P2Y familiji GPCR receptora. Ta familija ima nekoliko receptorskih podtipova sa različitom farmakološkom selektivnošću. Ovaj receptor funkcioniše kao receptor za ekstracelularni ATP i ADP. U trombocitima ADP vezivanje dovodi do mobilizacije intracelularnih jona kalcijuma putem aktivacije fosfolipaze C, promene oblika trombocita, i verovatno doprinosi njihovoj agregaciji.[2]
Vidi još
Literatura
- ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (1996). „Cloning and chromosomal localization of the human P2Y1 purinoceptor”. Biochem Biophys Res Commun. 218 (3): 783—8. PMID 8579591. doi:10.1006/bbrc.1996.0139.
- ^ „Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1”.
Dodatna literatura
- Janssens R; Communi D; Pirotton S; et al. (1996). „Cloning and tissue distribution of the human P2Y1 receptor.”. Biochem. Biophys. Res. Commun.. 221 (3): 588—93. PMID 8630005. doi:10.1006/bbrc.1996.0640.
- Léon C, Vial C, Cazenave JP, Gachet C (1996). „Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.”. Gene. 171 (2): 295—7. PMID 8666290. doi:10.1016/0378-1119(96)00027-3.
- Léon C; Hechler B; Vial C; et al. (1997). „The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.”. FEBS Lett.. 403 (1): 26—30. PMID 9038354. doi:10.1016/S0014-5793(97)00022-7.
- Ayyanathan K, Naylor SL, Kunapuli SP (1997). „Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1).”. Somat. Cell Mol. Genet.. 22 (5): 419—24. PMID 9039850. doi:10.1007/BF02369897.
- Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun.. 237 (2): 297—302. PMID 9268704. doi:10.1006/bbrc.1997.7135.
- Jin J, Daniel JL, Kunapuli SP (1998). „Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.”. J. Biol. Chem.. 273 (4): 2030—4. PMID 9442040. doi:10.1074/jbc.273.4.2030.
- Hall RA; Ostedgaard LS; Premont RT; et al. (1998). „A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.”. Proc. Natl. Acad. Sci. U.S.A.. 95 (15): 8496—501. PMC 21104
. PMID 9671706. doi:10.1073/pnas.95.15.8496. - Sabala P; Czajkowski R; Przybyłek K; et al. (2001). „Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.”. Br. J. Pharmacol.. 132 (2): 393—402. PMC 1572584 . PMID 11159687. doi:10.1038/sj.bjp.0703843.
- Yoshioka K, Saitoh O, Nakata H (2001). „Heteromeric association creates a P2Y-like adenosine receptor.”. Proc. Natl. Acad. Sci. U.S.A.. 98 (13): 7617—22. PMC 34717 . PMID 11390975. doi:10.1073/pnas.121587098.
- James G, Butt AM (2001). „Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve.”. Neurosci. Lett.. 312 (1): 33—6. PMID 11578839. doi:10.1016/S0304-3940(01)02189-9.
- Moore DJ; Chambers JK; Wahlin JP; et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta. 1521 (1-3): 107—19. PMID 11690642.
- Czajkowski R, Lei L, Sabała P, Barańska J (2002). „ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).”. FEBS Lett.. 513 (2-3): 179—83. PMID 11904146. doi:10.1016/S0014-5793(02)02255-X.
- Aktas B, Hönig-Liedl P, Walter U, Geiger J (2002). „Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.”. Biochem. Pharmacol.. 64 (3): 433—9. PMID 12147294. doi:10.1016/S0006-2952(02)01113-9.
- Nurden P; Poujol C; Winckler J; et al. (2003). „Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.”. Blood. 101 (4): 1400—8. PMID 12393588. doi:10.1182/blood-2002-02-0642.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). „Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.”. J. Invest. Dermatol.. 120 (3): 440—7. PMID 12603858. doi:10.1046/j.1523-1747.2003.12050.x.
- Jagroop IA, Burnstock G, Mikhailidis DP (2003). „Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets.”. Platelets. 14 (1): 15—20. PMID 12623443. doi:10.1080/0953710021000062914.
- Greig AV; Linge C; Terenghi G; et al. (2003). „Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.”. J. Invest. Dermatol.. 120 (6): 1007—15. PMID 12787128. doi:10.1046/j.1523-1747.2003.12261.x.
- Wang L; Ostberg O; Wihlborg AK; et al. (2003). „Quantification of ADP and ATP receptor expression in human platelets.”. J. Thromb. Haemost.. 1 (2): 330—6. PMID 12871508. doi:10.1046/j.1538-7836.2003.00070.x.
- „P2Y Receptors: P2Y1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г..
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