GPR50
| G protein-spregnuti receptor 50 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR50; H9; MGC125342 | ||||||||||
| Vanjski ID | OMIM: 300207 MGI: 1333877 HomoloGene: 3113 IUPHAR: GPR50 GeneCards: GPR50 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9248 | 14765 | |||||||||
| Ensembl | ENSG00000102195 | ENSMUSG00000056380 | |||||||||
| UniProt | Q13585 | Q3V1S8 | |||||||||
| RefSeq (mRNA) | NM_004224 | XM_990925 | |||||||||
| RefSeq (protein) | NP_004215 | XP_996019 | |||||||||
| Lokacija (UCSC) |
Chr X: 150.1 - 150.1 Mb |
Chr X: 67.92 - 67.93 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR50, G protein-spregnuti receptor 50, je protein koji je kod čoveka kodiran GPR50 genom.[1][2][3]
Funkcija
GPR50 je član GPCR familije integralnih membranskih proteina. On je sličan melatoninskom receptoru.[2] GPR50 ima sposobnost formiranja heterodimera sa MT1 i MT2 melatoninskim receptorima. Dok GPR50 nema uticaja na MT2 funkciju, on sprečava MT1 da veže melatonin i formira kompleks sa G proteinima.[4]
Klinički značaj
Određeni polimorfizmi GPR50 gena kod žena su povezani sa povišenim rizikom razvoja bipolarnog poremećaja, kliničkom depresijom, i šizofrenijom.[5] Drugi GPR50 genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih triglicerida i sniženje nivoa cirkulišućih lipoproteina visoke gustine.[6]
Reference
- ^ „Entrez Gene: GPR50 G protein-coupled receptor 50”.
- ^ а б Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters. 386 (2-3): 219—24. PMID 8647286. doi:10.1016/0014-5793(96)00437-1.
- ^ Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics. 55 (2): 248—51. PMID 9933574. doi:10.1006/geno.1998.5661.
- ^ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal. 25 (13): 3012—23. PMC 1500982
. PMID 16778767. doi:10.1038/sj.emboj.7601193.
- ^ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry. 10 (5): 470—8. PMID 15452587. doi:10.1038/sj.mp.4001593.
- ^ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research. 47 (4): 761—6. PMID 16436372. doi:10.1194/jlr.M500338-JLR200.
Literatura
- Reppert SM; Weaver DR; Ebisawa T; et al. (1996). „Cloning of a melatonin-related receptor from human pituitary.”. FEBS Lett.. 386 (2-3): 219—24. PMID 8647286. doi:10.1016/0014-5793(96)00437-1.
- Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).”. Genomics. 55 (2): 248—51. PMID 9933574. doi:10.1006/geno.1998.5661.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Slominski A; Pisarchik A; Zbytek B; et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin.”. J. Cell. Physiol.. 196 (1): 144—53. PMID 12767050. doi:10.1002/jcp.10287.
- Suzuki Y; Yamashita R; Shirota M; et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res.. 14 (9): 1711—8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604.
- Thomson PA; Wray NR; Thomson AM; et al. (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.”. Mol. Psychiatry. 10 (5): 470—8. PMID 15452587. doi:10.1038/sj.mp.4001593.
- Bhattacharyya S; Luan J; Challis B; et al. (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.”. J. Lipid Res.. 47 (4): 761—6. PMID 16436372. doi:10.1194/jlr.M500338-JLR200.
- Levoye A; Dam J; Ayoub MA; et al. (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.”. EMBO J.. 25 (13): 3012—23. PMC 1500982 . PMID 16778767. doi:10.1038/sj.emboj.7601193.
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