TAS2R14
| Receptor ukusa tip 2 član 14 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R14; T2R14; TRB1 | ||||||||||
| Vanjski ID | OMIM: 604790 MGI: 2681298 HomoloGene: 87013 IUPHAR: GeneCards: TAS2R14 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 50840 | 387616 | |||||||||
| Ensembl | ENSG00000212127 | ENSMUSG00000071147 | |||||||||
| UniProt | Q9NYV8 | Q7TQA4 | |||||||||
| RefSeq (mRNA) | NM_023922.1 | NM_021562.1 | |||||||||
| RefSeq (protein) | NP_076411.1 | NP_067537.1 | |||||||||
| Lokacija (UCSC) |
Chr 12: 11.09 - 11.32 Mb |
Chr 6: 133 - 133.01 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor ukusa tip 2 član 14 je protein koji je kod ljudi kodiran TAS2R14 genom.[1][2][3]
Funkcije
Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Istraživanja funkcionalne ekspresije su pokazala da TAS2R14 proizvodi respons na (-)-α-tujon, primarni neurotoksični agens u absintu, i pikrotoksinu, otrovu prisutnom u bobicama biljke Anamirta cocculus.[4] Ovaj gen se nalazi u genskom klasteru na hromozomu 12p13.[3]
Reference
- ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). „A novel family of mammalian taste receptors”. Cell. 100 (6): 693—702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.
- ^ Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse”. Nature. 404 (6778): 601—4. PMID 10766242. doi:10.1038/35007072.
- ^ а б „Entrez Gene: TAS2R14 taste receptor, type 2, member 14”.
- ^ Behrens, M., A. Brockhoff, C. Kuhn, B. Bufe, M. Winnig, and W. Meyerhof (2004). „The human taste receptor hTAS2R14 responds to a variety of different bitter compounds”. Biochem Biophys Res Commun. 319 (2): 479—485. PMID 15178431. doi:10.1016/j.bbrc.2004.05.019.
Literatura
- Kinnamon SC (2000). „A plethora of taste receptors”. Neuron. 25 (3): 507—10. PMID 10774719. doi:10.1016/S0896-6273(00)81054-5.
- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem.. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol.. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Chandrashekar J; Mueller KL; Hoon MA; et al. (2000). „T2Rs function as bitter taste receptors”. Cell. 100 (6): 703—11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol.. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
- Liu T; Qian WJ; Gritsenko MA; et al. (2006). „Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry”. J. Proteome Res.. 4 (6): 2070—80. PMC 1850943 . PMID 16335952. doi:10.1021/pr0502065.
- Behrens M; Bartelt J; Reichling C; et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression”. J. Biol. Chem.. 281 (29): 20650—9. PMID 16720576. doi:10.1074/jbc.M513637200.
Vidi još
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.