GPR35
| G protein-spregnuti receptor 35 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR35; | ||||||||||
| Vanjski ID | OMIM: 602646 MGI: 1929509 HomoloGene: 3874 IUPHAR: GPR35 GeneCards: GPR35 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2859 | 64095 | |||||||||
| Ensembl | ENSG00000178623 | ENSMUSG00000026271 | |||||||||
| UniProt | Q9HC97 | Q3TBY9 | |||||||||
| RefSeq (mRNA) | NM_005301 | NM_022320 | |||||||||
| RefSeq (protein) | NP_005292 | NP_071715 | |||||||||
| Lokacija (UCSC) |
Chr 2: 241.22 - 241.22 Mb |
Chr 1: 94.62 - 94.82 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR35, G protein-spregnuti receptor 35, je protein koji je kod čoveka kodiran GPR35 genom.[1] Povišeno izražavanje GPR35 receptora je nađeno u imunskim i gastrointestinalnim tkivima.
Ligandi
Jedna studija je pokazala da kinurenska kiselina deluje kao endogeni ligand ovog receptora.[2] Za zaprinast, PDE5A inhibitor, je isto tako nađeno da je GPR35 agonist.[3]
Klinički značaj
Brisanje GPR35 gena može da izazove simptome mentalne retardacije. Ovaj gen je mutiran kod 2q37 monosomije i sindroma 2q37 delecije.[4] Jedna studija je utvrdila da je GPR35 potencijalni onkogen raka želuca.[5]
Literatura
- ^ O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR (1998). „Discovery of three novel G-protein-coupled receptor genes”. Genomics. 47 (2): 310—3. PMID 9479505. doi:10.1006/geno.1998.5095.
- ^ Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006). „Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35”. J. Biol. Chem.. 281 (31): 22021—8. PMID 16754668. doi:10.1074/jbc.M603503200.free fulltext Архивирано на веб-сајту Wayback Machine (17. фебруар 2009)
- ^ Taniguchi Y, Tonai-Kachi H, Shinjo K (2006). „Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35”. FEBS Lett.. 580 (21): 5003—8. PMID 16934253. doi:10.1016/j.febslet.2006.08.015.
- ^ Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ (2004). „Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype”. Clin. Genet.. 66 (6): 537—44. PMID 15521982. doi:10.1111/j.1399-0004.2004.00363.x.
- ^ Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K (2004). „Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells”. Cancer Sci.. 95 (2): 131—5. PMID 14965362. doi:10.1111/j.1349-7006.2004.tb03193.x.
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