OPN3
| Opsin 3 (encefalopsin, panopsin) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OPN3; ECPN | ||||||||||
| Vanjski ID | OMIM: 606695 MGI: 1338022 HomoloGene: 40707 IUPHAR: OPN3 GeneCards: OPN3 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 23596 | 13603 | |||||||||
| Ensembl | ENSG00000054277 | ENSMUSG00000026525 | |||||||||
| UniProt | Q9H1Y3 | Q3KR48 | |||||||||
| RefSeq (mRNA) | NM_001030011 | NM_010098 | |||||||||
| RefSeq (protein) | NP_001025182 | NP_034228 | |||||||||
| Lokacija (UCSC) |
Chr 1: 239.82 - 239.87 Mb |
Chr 1: 177.5 - 177.53 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
OPN3, ili Opsin-3, je protein koji je kod čoveka kodiran OPN3 genom.[1][2][3] Alternativno splajsovanje ovog gena proizvodi više transkriptnih varijanti, koje kodiraju različite proteinske izoforme.
Funkcija
Opsini su članovi familije G protein-spregnutih receptora. Osim vizuelnih opsina, sisari poseduje nekoliko fotoreceptivnih ne-vizuelnih opsina koji su izraženi u tkivima izvan oka. Gen opsina-3 je u znatnoj meri izražen u mozgu i testisima, a u maloj meri i u jetri, materici, srcu, plućima, skeletalnim mišima, bubrezima, i pankreasu. Ovaj gene isto tako može da bude izražen u mrežnjači. Ovaj protein poseduje kanoničke osobine fotoreceptivnih opsina.[3]
Literatura
- ^ Blackshaw S, Snyder SH (1999). „Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain”. J Neurosci. 19 (10): 3681—90. PMID 10234000.
- ^ Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM (2001). „Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43”. Genomics. 72 (2): 203—8. PMID 11401433. doi:10.1006/geno.2001.6469.
- ^ а б „Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)”.
Dodatna literatura
- Bonaldo MF; Lennon G; Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res.. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791.
- Halford S; Bellingham J; Ocaka L; et al. (2002). „Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids.”. Cytogenet. Cell Genet.. 95 (3-4): 234—5. PMID 12063405. doi:10.1159/000059351.
- Kasper G; Taudien S; Staub E; et al. (2003). „Different structural organization of the encephalopsin gene in man and mouse.”. Gene. 295 (1): 27—32. PMID 12242008. doi:10.1016/S0378-1119(02)00799-0.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Alam NA; Gorman P; Jaeger EE; et al. (2004). „Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.”. Cancer Genet. Cytogenet.. 147 (2): 121—7. PMID 14623461. doi:10.1016/S0165-4608(03)00196-1.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Gregory SG; Barlow KF; McLay KE; et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature. 441 (7091): 315—21. PMID 16710414. doi:10.1038/nature04727.
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