S1PR3
| Sfingozin-1-fosfatni receptor 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | S1PR3; EDG-3; EDG3; LPB3; S1P3 | ||||||||||
| Vanjski ID | OMIM: 601965 MGI: 1339365 HomoloGene: 3829 IUPHAR: S1P3 | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | n/a | 13610 | |||||||||
| Ensembl | ENSG00000213694 | ENSMUSG00000067586 | |||||||||
| UniProt | Q99500 | Q9Z0U9 | |||||||||
| RefSeq (mRNA) | NM_005226.3 | NM_010101.4 | |||||||||
| RefSeq (protein) | NP_005217.2 | NP_034231.1 | |||||||||
| Lokacija (UCSC) |
Chr 9: 91.61 - 91.62 Mb |
Chr 13: 51.5 - 51.52 Mb | |||||||||
| PubMed pretraga | n/a | [1] | |||||||||
Sfingozin-1-fosfatni receptor 3 je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P). stoga je ovaj receptor takođe poznat kao S1P3.[1]
Funkcija
Ovaj protein je član EDG familije receptora. On doprinosi regulaciji angiogeneze i funkcija vaskularnih endotelnih ćelija.[1]
Reference
Literatura
- Hla T; Lee MJ; Ancellin N; et al. (2000). „Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci.. 905: 16—24. PMID 10818438. doi:10.1111/j.1749-6632.2000.tb06534.x.
- Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci.. 905: 54—60. PMID 10818441. doi:10.1111/j.1749-6632.2000.tb06537.x.
- Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). „Phospholipid growth factors and corneal wound healing.”. Ann. N. Y. Acad. Sci.. 905: 142—58. PMID 10818450. doi:10.1111/j.1749-6632.2000.tb06546.x.
- Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”. Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496—502. PMID 11915348.
- Van Koppen CJ; Meyer Zu Heringdorf D; Zhang C; et al. (1996). „A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.”. Mol. Pharmacol.. 49 (6): 956—61. PMID 8649355.
- Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). „Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.”. Biochem. Biophys. Res. Commun.. 227 (2): 608—14. PMID 8878560. doi:10.1006/bbrc.1996.1553.
- An S; Bleu T; Huang W; et al. (1998). „Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”. FEBS Lett.. 417 (3): 279—82. PMID 9409733. doi:10.1016/S0014-5793(97)01301-X.
- Van Brocklyn JR; Tu Z; Edsall LC; et al. (1999). „Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.”. J. Biol. Chem.. 274 (8): 4626—32. PMID 9988698. doi:10.1074/jbc.274.8.4626.
- Zhang Q; Peyruchaud O; French KJ; et al. (1999). „Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway.”. Blood. 93 (9): 2984—90. PMID 10216094.
- Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”. J. Biol. Chem.. 274 (27): 18997—9002. PMID 10383399. doi:10.1074/jbc.274.27.18997.
- Windh RT; Lee MJ; Hla T; et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem.. 274 (39): 27351—8. PMID 10488065. doi:10.1074/jbc.274.39.27351.
- Goetzl EJ; Dolezalova H; Kong Y; et al. (1999). „Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.”. Cancer Res.. 59 (20): 5370—5. PMID 10537322.
- Lee MJ; Thangada S; Claffey KP; et al. (1999). „Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.”. Cell. 99 (3): 301—12. PMID 10555146. doi:10.1016/S0092-8674(00)81661-X.
- An S, Zheng Y, Bleu T (2000). „Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.”. J. Biol. Chem.. 275 (1): 288—96. PMID 10617617. doi:10.1074/jbc.275.1.288.
- Orlati S; Porcelli AM; Hrelia S; et al. (2000). „Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.”. Arch. Biochem. Biophys.. 375 (1): 69—77. PMID 10683250. doi:10.1006/abbi.1999.1589.
- Lee H, Goetzl EJ, An S (2000). „Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.”. Am. J. Physiol., Cell Physiol.. 278 (3): C612—8. PMID 10712250.
- Kimura T; Watanabe T; Sato K; et al. (2000). „Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.”. Biochem. J.. 348 Pt 1: 71—6. PMID 10794715. doi:10.1042/0264-6021:3480071.
Vidi još
Spoljašnje veze
- „Lysophospholipid Receptors: S1P3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г..
- Lysophospholipid+receptors на US National Library of Medicine Medical Subject Headings (MeSH)
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