RAIG

G protein spregnuti receptor, familija C, grupa 5, član A
Identifikatori
SimbolGPRC5A
Alt. simboliRAIG1, RAI3
Entrez9052
HUGO9836
OMIM604138
RefSeqNM_003979
UniProtQ8NFJ5
Ostali podaci
LokusHromozom 12 p13-p12.3
G protein spregnuti receptor, familija C, grupa 5, član B
Identifikatori
SimbolGPRC5B
Alt. simboliRAIG2
Entrez51704
HUGO13308
OMIM605948
RefSeqNM_016235
UniProtQ9NZH0
Ostali podaci
LokusHromozom 16 p12
G protein spregnuti receptor, familija C, grupa 5, član C
Identifikatori
SimbolGPRC5C
Alt. simboliRAIG3
Entrez55890
HUGO13309
OMIM605949
RefSeqNM_022036
UniProtQ9NQ84
Ostali podaci
LokusHromozom 17 q25
G protein spregnuti receptor, familija C, grupa 5, član D
Identifikatori
SimbolGPRC5D
Entrez55507
HUGO13310
OMIM607437
RefSeqNM_018654
UniProtQ9NZD1
Ostali podaci
LokusHromozom 12 p13.3

RAIG (Retinoinskom kiselinom inducibilni orfan G protein spregnuti receptori) su grupa od četiri blisko srodna G protein spregnuta receptora čije izražavanje je indukovano retinoinskom kiselinom.[1][2][3][4]

Funkcija ovih proteina nije određena. Pretpostavlja se da oni mogu da pruže mehanizam kojim retinoinska kiselina može da utiče na G proteinsku signalnu kaskadu. Osim toga, RAIG receptori formiraju interakcije sa članovima klase uvojitih G protein spregnutih receptora i potencijalno aktiviraju Wnt signalni put.[5]

Reference

  1. ^ Cheng Y, Lotan R (1998). „Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor”. J. Biol. Chem.. 273 (52): 35008—15. PMID 9857033. doi:10.1074/jbc.273.52.35008. 
  2. ^ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics. 65 (2): 121—8. PMID 10783259. doi:10.1006/geno.2000.6164. 
  3. ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics. 67 (1): 8—18. PMID 10945465. doi:10.1006/geno.2000.6226. 
  4. ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). „Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D”. Biochim. Biophys. Acta. 1518 (3): 237—48. PMID 11311935. 
  5. ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). „Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling”. Biochem. Biophys. Res. Commun.. 358 (4): 968—75. PMC 2854581 Слободан приступ. PMID 17521608. doi:10.1016/j.bbrc.2007.04.208. 

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