OR2A4
| Olfaktorni receptor, familija 2, potfamilija A, član 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OR2A4; OR2A10 | ||||||||||
| Vanjski ID | MGI: 104812 HomoloGene: 27232 GeneCards: OR2A4 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 79541 | 18310 | |||||||||
| Ensembl | ENSG00000180658 | ENSMUSG00000043605 | |||||||||
| UniProt | O95047 | P34984 | |||||||||
| RefSeq (mRNA) | NM_030908.1 | NM_146652.1 | |||||||||
| RefSeq (protein) | NP_112170.1 | NP_666863.1 | |||||||||
| Lokacija (UCSC) |
Chr 6: 132.02 - 132.02 Mb |
Chr 6: 43.17 - 43.18 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 2A4 je protein koji je kod ljudi kodiran OR2A4 genom.[1]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[1]
Reference
Literatura
- Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000). „Shotgun sequencing of the human transcriptome with ORF expressed sequence tags”. Proc. Natl. Acad. Sci. U.S.A.. 97 (7): 3491—6. PMC 16267
. PMID 10737800. doi:10.1073/pnas.97.7.3491. - Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Mungall AJ; Palmer SA; Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
- Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A.. 101 (8): 2584—9. PMC 356993 . PMID 14983052. doi:10.1073/pnas.0307882100.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Vidi još
Spoljašnje veze
- OR2A4+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
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