OR2H2
| Olfaktorni receptor, familija 2, potfamilija H, član 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OR2H2; FAT11; OLFR2; OLFR42B; OR2H3; dJ271M21.2; hs6M1-12 | ||||||||||
| Vanjski ID | OMIM: 600578 MGI: 2177473 HomoloGene: 68546 GeneCards: OR2H2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 7932 | 258469 | |||||||||
| Ensembl | ENSG00000204657 | ENSMUSG00000056600 | |||||||||
| UniProt | O95918 | Q0VEL5 | |||||||||
| RefSeq (mRNA) | NM_007160.3 | NM_146477.2 | |||||||||
| RefSeq (protein) | NP_009091.3 | NP_666688.2 | |||||||||
| Lokacija (UCSC) |
Chr 6: 29.56 - 29.56 Mb |
Chr 17: 37.09 - 37.09 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 2H2 je protein koji je kod ljudi kodiran OR2H2 genom.[1]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[1]
Reference
Literatura
- Fan W, Liu YC, Parimoo S, Weissman SM (1995). „Olfactory receptor-like genes are located in the human major histocompatibility complex.”. Genomics. 27 (1): 119—23. PMID 7665158. doi:10.1006/geno.1995.1013.
- Fan W; Cai W; Parimoo S; et al. (1996). „Identification of seven new human MHC class I region genes around the HLA-F locus.”. Immunogenetics. 44 (2): 97—103. PMID 8662070. doi:10.1007/BF02660056.
- Eklund AC; Belchak MM; Lapidos K; et al. (2000). „Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites.”. Hum. Immunol.. 61 (7): 711—7. PMID 10880742. doi:10.1016/S0198-8859(00)00132-4.
- Younger RM; Amadou C; Bethel G; et al. (2001). „Characterization of clustered MHC-linked olfactory receptor genes in human and mouse.”. Genome Res.. 11 (4): 519—30. PMC 311051
. PMID 11282967. doi:10.1101/gr.160301. - Fuchs T; Malecova B; Linhart C; et al. (2003). „DEFOG: a practical scheme for deciphering families of genes.”. Genomics. 80 (3): 295—302. PMID 12213199. doi:10.1006/geno.2002.6830.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Volz A; Ehlers A; Younger R; et al. (2003). „Complex transcription and splicing of odorant receptor genes.”. J. Biol. Chem.. 278 (22): 19691—701. PMID 12637542. doi:10.1074/jbc.M212424200.
- Mungall AJ; Palmer SA; Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
- Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family.”. Proc. Natl. Acad. Sci. U.S.A.. 101 (8): 2584—9. PMC 356993 . PMID 14983052. doi:10.1073/pnas.0307882100.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Santos PS; Kellermann T; Uchanska-Ziegler B; et al. (2010). „Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.”. Immunogenetics.. 62 (9): 569—84. PMID 20680261. doi:10.1007/s00251-010-0468-6.
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Spoljašnje veze
- OR2H2+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
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