OR3A4

Olfaktorni receptor, familija 3, potfamilija A, član 4 pseudogen
Identifikatori
Simboli OR3A4P; OLFRA05; OLFRA06; OR17-13; OR17-16; OR17-24; OR17-25; OR24; OR25; OR3A4; OR3A5P
Vanjski ID MGI: 3030233 HomoloGene: 27325 GeneCards: OR3A4P Gene
Ortolozi
Vrsta Čovek Miš
Entrez 390756 259006
Ensembl ENSG00000180068 ENSMUSG00000043692
UniProt P47883 n/a
RefSeq (mRNA) NM_001005334.1 NM_147004
RefSeq (protein) NP_001005334 NP_667215
Lokacija (UCSC) Chr 17:
3.21 - 3.22 Mb		 Chr 11:
73.87 - 73.87 Mb
PubMed pretraga [1] [2]

Olfaktorni receptor 3A4 je protein koji je kod ljudi kodiran OR3A4 genom.[1]

Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[1]

Reference

Literatura

  • Ben-Arie N; Lancet D; Taylor C; et al. (1994). „Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire”. Hum. Mol. Genet.. 3 (2): 229—35. PMID 8004088. doi:10.1093/hmg/3.2.229. 
  • Glusman G, Clifton S, Roe B, Lancet D (1997). „Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity”. Genomics. 37 (2): 147—60. PMID 8921386. doi:10.1006/geno.1996.0536. 
  • Glusman G; Sosinsky A; Ben-Asher E; et al. (2000). „Sequence, structure, and evolution of a complete human olfactory receptor gene cluster”. Genomics. 63 (2): 227—45. PMID 10673334. doi:10.1006/geno.1999.6030. 
  • Fuchs T; Malecova B; Linhart C; et al. (2003). „DEFOG: a practical scheme for deciphering families of genes”. Genomics. 80 (3): 295—302. PMID 12213199. doi:10.1006/geno.2002.6830. 
  • Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A.. 101 (8): 2584—9. PMC 356993 Слободан приступ. PMID 14983052. doi:10.1073/pnas.0307882100. 

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