OR2AE1

Olfaktorni receptor, familija 2, potfamilija AE, član 1
Identifikatori
Simboli OR2AE1; OR2AE2
Vanjski ID MGI: 3030004 HomoloGene: 128272 GeneCards: OR2AE1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 81392 258959
Ensembl ENSG00000244623 ENSMUSG00000062245
UniProt Q8NHA4 n/a
RefSeq (mRNA) NM_001005276.1 NM_146957
RefSeq (protein) NP_001005276.1 NP_667168
Lokacija (UCSC) Chr 7:
99.47 - 99.47 Mb		 Chr 16:
19.52 - 19.52 Mb
PubMed pretraga [1] [2]

Olfaktorni receptor 2AE1 je protein koji je kod ljudi kodiran OR2AE1 genom.[1]

Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[1]

Reference

Literatura

  • „Toward a complete human genome sequence.”. Genome Res.. 8 (11): 1097—108. 1999. PMID 9847074. doi:10.1101/gr.8.11.1097. 
  • Thompson EE; Kuttab-Boulos H; Yang L; et al. (2006). „Sequence diversity and haplotype structure at the human CYP3A cluster.”. Pharmacogenomics J.. 6 (2): 105—14. PMID 16314882. doi:10.1038/sj.tpj.6500347. 

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