OR3A2
| Olfaktorni receptor, familija 3, potfamilija A, član 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OR3A2; OLFRA04; OR17-14; OR17-228; OR228 | ||||||||||
| Vanjski ID | MGI: 3030244 HomoloGene: 68262 GeneCards: OR3A2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4995 | 258702 | |||||||||
| Ensembl | ENSG00000221882 | ENSMUSG00000063116 | |||||||||
| UniProt | P47893 | Q8VFX8 | |||||||||
| RefSeq (mRNA) | NM_002551.3 | NM_146707.1 | |||||||||
| RefSeq (protein) | NP_002542.3 | NP_666918.1 | |||||||||
| Lokacija (UCSC) |
Chr 17: 3.18 - 3.18 Mb |
Chr 11: 74.33 - 74.34 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 3A2 je protein koji je kod ljudi kodiran OR3A2 genom.[1][2][3]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[3]
Reference
- ^ Glusman G, Clifton S, Roe B, Lancet D (1997). „Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity”. Genomics. 37 (2): 147—60. PMID 8921386. doi:10.1006/geno.1996.0536.
- ^ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (2000). „Sequence, structure, and evolution of a complete human olfactory receptor gene cluster”. Genomics. 63 (2): 227—45. PMID 10673334. doi:10.1006/geno.1999.6030.
- ^ а б „Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2”.
Literatura
- Ben-Arie N; Lancet D; Taylor C; et al. (1994). „Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.”. Hum. Mol. Genet.. 3 (2): 229—35. PMID 8004088. doi:10.1093/hmg/3.2.229.
- Rouquier S; Taviaux S; Trask BJ; et al. (1998). „Distribution of olfactory receptor genes in the human genome.”. Nat. Genet.. 18 (3): 243—50. PMID 9500546. doi:10.1038/ng0398-243.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family.”. Proc. Natl. Acad. Sci. U.S.A.. 101 (8): 2584—9. PMC 356993 . PMID 14983052. doi:10.1073/pnas.0307882100.
Vidi još
Spoljašnje veze
- OR3A2+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
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