OR3A3
| Olfaktorni receptor, familija 3, potfamilija A, član 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OR3A3; OR17-137; OR17-16; OR17-201; OR3A6; OR3A7; OR3A8P | ||||||||||
| Vanjski ID | MGI: 3030245 HomoloGene: 74999 GeneCards: OR3A3 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8392 | 258704 | |||||||||
| Ensembl | ENSG00000159961 | ENSMUSG00000054406 | |||||||||
| UniProt | P47888 | Q7TRW8 | |||||||||
| RefSeq (mRNA) | NM_012373.2 | NM_146709.2 | |||||||||
| RefSeq (protein) | NP_036505.2 | NP_666920.2 | |||||||||
| Lokacija (UCSC) |
Chr 17: 3.32 - 3.32 Mb |
Chr 11: 74.35 - 74.35 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 3A3 je protein koji je kod ljudi kodiran OR3A3 genom.[1][2][3]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[3]
Reference
- ^ Ben-Arie N; Lancet D; Taylor C; Khen M; Walker N; Ledbetter DH; Carrozzo R; Patel K; Sheer D (1994). „Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire”. Hum Mol Genet. 3 (2): 229—35. PMID 8004088. doi:10.1093/hmg/3.2.229.
- ^ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (1998). „Distribution of olfactory receptor genes in the human genome”. Nat Genet. 18 (3): 243—50. PMID 9500546. doi:10.1038/ng0398-243.
- ^ а б „Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3”.
Literatura
- Zody MC; Garber M; Adams DJ; et al. (2006). „DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage”. Nature. 440 (7087): 1045—9. PMC 2610434
. PMID 16625196. doi:10.1038/nature04689. - Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A.. 101 (8): 2584—9. PMC 356993 . PMID 14983052. doi:10.1073/pnas.0307882100.
- Gilad Y, Lancet D (2003). „Population differences in the human functional olfactory repertoire”. Mol. Biol. Evol.. 20 (3): 307—14. PMID 12644552. doi:10.1093/molbev/msg013.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Fuchs T; Malecova B; Linhart C; et al. (2003). „DEFOG: a practical scheme for deciphering families of genes”. Genomics. 80 (3): 295—302. PMID 12213199. doi:10.1006/geno.2002.6830.
- Glusman G; Sosinsky A; Ben-Asher E; et al. (2000). „Sequence, structure, and evolution of a complete human olfactory receptor gene cluster”. Genomics. 63 (2): 227—45. PMID 10673334. doi:10.1006/geno.1999.6030.
Vidi još
Spoljašnje veze
- OR3A3+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
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